Clinical Chemistry
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Clinical Chemistry 20: 486-491, 1974;
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Clinical Chemistry, Vol 20, 486-491, Copyright © 1974 by the American Association for Clinical Chemistry

Comparison of Four Indexes to Fetal Pulmonary Maturity

Arthur F. Rosenthal 1, Marta G. Vargas 1, and Selma V. Schiff 1

1 Department of Laboratories, The Long Island Jewish/Hillside Medical Center, New Hyde Park, N. Y. 11040.

With use of the same amniotic fluid specimens, lecithin concentration was compared with nonchromatographically determined glycerophospholipid, total lipid phosphorus, and the bubble-stability test as indexes of fetal lung maturation. The lecithin analysis was performed by thin-layer chromatography, with use of a semiautomated method of spotting and nondigestive release of phosphorus from the separated spots. We conclude that, next to the chromatographic analysis, the best tests are glycerophosphatide P, the bubble-stability test, and total lipid P, in that descending order. Lecithin determination as compared with densitometric evaluation of the lecithin/sphingomyelin ratio is discussed.


Key Words: amniotic fluid • phospholipids • glycerophosphatides • thin-layer chromatography • fetal maturity • respiratory distress syndrome • bubble-stability test • lecithin

Submitted on June 25, 1973
Accepted on February 11, 1974






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Copyright © 1974 by the American Association for Clinical Chemistry.