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Clinical Chemistry 20: 571-573, 1974;
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Clinical Chemistry, Vol 20, 571-573, Copyright © 1974 by the American Association for Clinical Chemistry

Measurement of IgG and Albumin Content of Cerebrospinal Fluid, and its Interpretation

Karin Ganrot 1 and Carl-Bertil Laurell 1

1 Department of Clinical Chemistry, University of Lund, Malmö General Hospital, Malmö, Sweden.

A high correlation (r = 0.85) normally exists between the concentration of albumin and of IgG in cerebrospinal fluid (CSF). The correlation is still better (r = 0.96) if the concentrations of the two proteins are also measured in plasma and the CSF/ plasma ratios compared for albumin and IgG. The scatter diagram for these ratios in persons without disease of the nervous system is most useful as a reference when differentiating between local IgG production in the subarachnoid space and an increase in CSF protein for other reasons. The analysis can be performed on less than 0.1 ml of CSF, in contrast to agarose-gel electrophoresis, for which 5-10 ml is necessary.


Key Words: blood-brain barrier • disease of the nervous system • diagnostic aid • multiple sclerosis • electroimmunoassay • subarachnoid IgG production • normal values

Submitted on February 5, 1974
Accepted on February 19, 1974




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Copyright © 1974 by the American Association for Clinical Chemistry.