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Clinical Chemistry 20: 591-594, 1974;
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Clinical Chemistry, Vol 20, 591-594, Copyright © 1974 by the American Association for Clinical Chemistry

Standardization in Abnormal Hemoglobin Detection. An Evaluation of Hemoglobin Electrophoresis Kits

Robert M. Schmidt 1 and Solomon Holland 1

1 Hematology Division, Center for Disease Control, Public Health Service, U. S. Department of HEW, 1600 Clifton Rd., Atlanta, Ga. 30333.

Three widely used commercial hemoglobin electrophoresis kits were studied to ascertain specificity, accuracy, precision, and characteristics of product information. Two hundred and ninety-six hemoglobin samples were used to evaluate each kit. Except for poor separation of hemoglobin F by one kit, all three kits gave generally satisfactory results. We give specific recommendations for improving these kits and for laboratory quality-control practices.


Key Words: screening • sickle-cell disease • hemoglobin phenotyping

Submitted on December 28, 1973
Accepted on March 6, 1974




The following articles in journals at HighWire Press have cited this article:


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H. C. Kim
Laboratory Identification of Inherited Hemoglobinopathies in Children
Clinical Pediatrics, March 1, 1981; 20(3): 161 - 171.
[Abstract] [PDF]


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Copyright © 1974 by the American Association for Clinical Chemistry.