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Clinical Chemistry 20: 639-641, 1974;
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Clinical Chemistry, Vol 20, 639-641, Copyright © 1974 by the American Association for Clinical Chemistry

Mass Phenotyping of Isoniazid Inactivators by Automated Determination of Acetylisoniazid in Urine

P. Varughese 1, E. J. Hamilton 1, and L. Eidus 1

1 Laboratory Centre for Disease Control, Health Protection Branch, Health and Welfare Canada, Ottawa, Ontario, Canada K1A 0L2.

An automated procedure is described for phenotyping isoniazid inactivators. The method is based on the color reaction produced by N-acetylisoniazid in aqueous solution, as described by Eidus and Hamilton [Amer. Rev. Resp. Dis. 89, 587 (1964)]. Maximum sampling rate is 60 samples per hour. Results of this procedure correlated well (r = 0.987) with those of a manual phenotyping method.


Key Words: AutoAnalyzer • treatment of tuberculosis • screening

Submitted on January 28, 1974
Accepted on February 21, 1974






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Copyright © 1974 by the American Association for Clinical Chemistry.