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Clinical Chemistry 20: 666-669, 1974;
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Clinical Chemistry, Vol 20, 666-669, Copyright © 1974 by the American Association for Clinical Chemistry

Screening Cord Bloods for Detection of Sickle Cell Disease in Jamaica

Beryl E. Serjeant 1, Miriam Forbes 1, Leslie L. Williams 1, and Graham R. Serjeant 1

1 Sickle Cell Section, MRC Epidemiology Unit, University of the West Indies,1 and Victoria Jubilee Hospital, Kingston, Jamaica.

A cord-blood screening program, designed primarily for detecting sickle cell disease, has been in operation for seven months (8000 samples) at a large maternity unit in Kingston, Jamaica. We describe techniques of cord-blood collection and electrophoretic investigation on both cellulose acetate and agar gel. These methods appear to give rapid, valid results at minimal expense and are well adapted to screening large populations.


Key Words: screening • diagnostic aids • electrophoresis on solid media • gene frequency

Submitted on February 27, 1974
Accepted on April 3, 1974




The following articles in journals at HighWire Press have cited this article:


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Arch Intern MedHome page
J. Thompson, M. Reid, I. Hambleton, and G. R. Serjeant
Albuminuria and Renal Function in Homozygous Sickle Cell Disease: Observations From a Cohort Study
Arch Intern Med, April 9, 2007; 167(7): 701 - 708.
[Abstract] [Full Text] [PDF]


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E. V. Haverfield, C. A. McKenzie, T. Forrester, N. Bouzekri, R. Harding, G. Serjeant, T. Walker, T. E. A. Peto, R. Ward, and D. J. Weatherall
UGT1A1 variation and gallstone formation in sickle cell disease
Blood, February 1, 2005; 105(3): 968 - 972.
[Abstract] [Full Text] [PDF]


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Am. J. Clin. Nutr.Home page
A. Singhal, S. Parker, L. Linsell, and G. Serjeant
Energy intake and resting metabolic rate in preschool Jamaican children with homozygous sickle cell disease
Am. J. Clinical Nutrition, June 1, 2002; 75(6): 1093 - 1097.
[Abstract] [Full Text] [PDF]


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Arch. Dis. Child.Home page
G R Serjeant, A Singhal, and I R Hambleton
Sickle cell disease and age at menarche in Jamaican girls: observations from a cohort study
Arch. Dis. Child., November 1, 2001; 85(5): 375 - 378.
[Abstract] [Full Text] [PDF]


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Arch. Dis. Child.Home page
P W Thomas, A Singhal, M Hemmings-Kelly, and G R Serjeant
Height and weight reference curves for homozygous sickle cell disease
Arch. Dis. Child., March 1, 2000; 82(3): 204 - 208.
[Abstract] [Full Text]


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BMJHome page
A. Lee, P. Thomas, L. Cupidore, B. Serjeant, and G. Serjeant
Improved survival in homozygous sickle cell disease: lessons from a cohort study
BMJ, December 16, 1995; 311(7020): 1600 - 1602.
[Abstract] [Full Text]


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Arch Pediatr Adolesc MedHome page
J. H. Githens, P. A. Lane, R. S. McCurdy, M. L. Houston, J. D. McKinna, and D. M. Cole
Newborn Screening for Hemoglobinopathies in Colorado: The First 10 Years
Arch Pediatr Adolesc Med, April 1, 1990; 144(4): 466 - 470.
[Abstract] [PDF]


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CLIN PEDIATRHome page
M.C.G. Stevens, M. Padwick, and G.R. Serjeant
Observations on the Natural History of Dactylitis in Homozygous Sickle Cell Disease
Clinical Pediatrics, May 1, 1981; 20(5): 311 - 317.
[Abstract] [PDF]


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JAMAHome page
M. S. Kramer, Y. Rooks, D. Johnston, and H. A. Pearson
Accuracy of Cord Blood Screening for Sickle Hemoglobinopathies: Three- to Five-Year Follow-up
JAMA, February 2, 1979; 241(5): 485 - 486.
[Abstract] [PDF]




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Copyright © 1974 by the American Association for Clinical Chemistry.