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Clinical Chemistry 20: 682-686, 1974;
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Clinical Chemistry, Vol 20, 682-686, Copyright © 1974 by the American Association for Clinical Chemistry

Plasma Corticotropin Radioimmunoassay, with Use of Fuller's Earth for Extraction

E. D. Horgan 1 and W. J. Riley 1

1 Department of Biochemistry, Royal Perth Hospital, Box X 2213, G.P.O., Perth, Western Australia 6001.

A radioimmunoassay is described for plasma corticotropin whereby concentrations over the range of 6 to 1000 ng/liter can be measured. Corticotropin extracted from plasma on fuller's earth under carefully standardized conditions is assayed by a long-used double antibody radioimmunoassay procedure. Within (n = 6) and between (n = 12) assay precision is 39 ± 2 (SD) ng/liter and 44 ± 6 (SD) ng/liter, respectively. Normal basal corticotropin concentrations in plasma collected between 8 a.m. and 10 a.m. ranged from 6 to 68 ng/liter. Corticotropin was not detected in hypophysectomized patients and in subjects pretreated with dexamethasone, but elevated concentrations were found in an Addisonian patient and in a patient with a thymoma.


Key Words: ACTH • hormones • Cushing's syndrome • diagnostic aid • normal values

Submitted on January 25, 1974
Accepted on April 11, 1974






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Copyright © 1974 by the American Association for Clinical Chemistry.