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Clinical Chemistry 20: 692-694, 1974;
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Clinical Chemistry, Vol 20, 692-694, Copyright © 1974 by the American Association for Clinical Chemistry

Rapid Ultraviolet Procedure for Measuring Doxepin and Some Doxepin Metabolites in Human Urine

Warren C. Randolph 1, Sidney S. Walkenstein 1, Gerald L. Joseph 1, and Alfred P. Intoccia 1

1 Research and Development Division, Smith Kline & French Laboratories, Philadelphia, Pa. 19101.

A method is described for measuring doxepin-related material excreted in urine. Unchanged doxepin and certain doxepin metabolites are oxidized to doxepin ketone with KMnO4. The doxepin ketone is extracted with n-hexane and quantitated by ultraviolet spectrophotometry at the absorption maximum, 266 nm. This method is fast, reproducible, and measures a greater percentage of doxepin-related material than do existing gas—liquid chromatographic procedures. Doxepin ketone was measured to provide bio-availability data, for comparison of different formulations in humans.

Submitted on December 10, 1973
Accepted on April 12, 1974






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Copyright © 1974 by the American Association for Clinical Chemistry.