Clinical Chemistry
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Clinical Chemistry 20: 775-782, 1974;
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Clinical Chemistry, Vol 20, 775-782, Copyright © 1974 by the American Association for Clinical Chemistry

Use of the Simplex Method to Optimize Analytical Conditions in Clinical Chemistry

Richard D. Krause 1 and John A. Lott 1

1 Division of Clinical Chemistry, Department of Pathology, Ohio State University, 410 West 10th Ave., Columbus, Ohio 43210.

The optimum analytical conditions with regard to two or more variables can be determined in an unambiguous way by use of the simplex method. The method is particularly applicable to problems involving interacting variables. We describe the application of the simplex technique to the optimization of two procedures on a continuous-flow analyzer (AutoAnalyzer) and to the optimization of chemical variables in the lactate dehydrogenase-catalyzed pyruvate-to-lactate reaction and certain instrumental variables on a centrifugal analyzer (the ENI-GEMSAEC).


Key Words: experimental design • GEMSAEC • centrifugal analyzer • lactate dehydrogenase • AutoAnalyzer • glucose analysis

Submitted on April 11, 1974
Accepted on May 2, 1974






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Copyright © 1974 by the American Association for Clinical Chemistry.