Clinical Chemistry
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Clinical Chemistry 20: 1009-1012, 1974;
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Clinical Chemistry, Vol 20, 1009-1012, Copyright © 1974 by the American Association for Clinical Chemistry

A Low-Noise Thermistor Bridge for Use in Calorimetry

Robert L. Berger 1, Walter S. Friauf 1, and Horace E. Cascio 1

1 National Institutes of Health, Public Health Service, U. S. Department of Health, Education and Welfare, Bethesda, Md. 20014.

A precision thermistor bridge and thermistor is described for use in a thermal titration calorimeter or a high-speed stopped- or continuous-flow calorimeter of the Roughton type. These are compared and evaluated with regard to several other types of detectors, including the platinum resistance thermometer, thermocouple, transistor thermometer, and capacitance thermometers. At this time the best detection for our purpose seems to be a specially constructed 20-100 kOHgr thermistor used in conjunction with a new ac lock-in amplifier bridge. The sensitivity of the system is equivalent to a peak-to-peak noise of 25 x 10-6 °C, with a 100-ms time constant and 1 µW power dissipation in the thermistor. Long-term drift of the bridge, without an oven, was 1 x 10-6 °C/min.

Submitted on April 4, 1974
Accepted on May 27, 1974






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Copyright © 1974 by the American Association for Clinical Chemistry.