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Clinical Chemistry 20: 942-949, 1974;
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Clinical Chemistry, Vol 20, 942-949, Copyright © 1974 by the American Association for Clinical Chemistry

A Centrifugal Analyzer with a New All-Digital Measurement System

J. Avery 1, R. P. Gregory IV 1, B. W. Renoe 1, T. Woodruff 1, and H. V. Malmstadt 1

1 Department of Chemistry, School of Chemical Sciences, University of Illinois, Urbana, Ill. 61801.

An accurate, all-digital measurement system has been developed for use in a centrifugal analyzer system. The output of the radiation detector is converted directly to a digital count by a new type of charge-to-count converter. The converter is characterized by exceptional linearity and stability, and has a wide dynamic range. A gating and counting unit integrates the output of the charge-to-count converter and simultaneously measures the period of integration. The integration effectively discriminates against noise and allows an optimum amount of information to be extracted from the signal during the measurement period. Measurement of the integration period reduces requirements for synchronization and control devices, thus simplifying overall analyzer design. Control and data manipulation functions are performed by a minicomputer. The programs were written in OS/8 FORTRAN. The basic measurement principles of the new system and test results are described.


Key Words: improved instrumentation • mechanized analysis • sources of error • blood glucose • computers

Submitted on April 3, 1974
Accepted on May 15, 1974






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Copyright © 1974 by the American Association for Clinical Chemistry.