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Clinical Chemistry 20: 966-972, 1974;
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Clinical Chemistry, Vol 20, 966-972, Copyright © 1974 by the American Association for Clinical Chemistry

Breath Analysis as a Technique in Clinical Chemistry

Kurt M. Dubowski 1

1 Departments of Medicine, Biochemistry and Molecular Biology, and Pathology, College of Medicine, University of Oklahoma, Oklahoma City, Okla. 73190.

Breath possesses unique advantages as a specimen for clinical chemical analyses, including the continuous equilibrium of gases and volatile substances between expired alveolar air and the pulmonary blood circulation. Substances amenable to analysis in breath include O2, CO2, CO, and other gases, volatile organic compounds, and many drugs with sufficiently high vapor pressures at physiological temperatures. Practical aspects of breath sampling and breath analysis are discussed, exemplified by breath-alcohol analysis. The requirements for obtaining breath samples in equilibrium with the pulmonary blood circulation are delineated, and experimental data are presented for the significant breath-sample characteristics bearing on design of breath collection and storage systems (end-expiratory temperature, breath volumes).


Key Words: toxicology • alveolar and deadspace gas • analysis of volatiles

Submitted on May 8, 1974
Accepted on May 24, 1974




The following articles in journals at HighWire Press have cited this article:


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[Abstract] [Full Text] [PDF]


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Copyright © 1974 by the American Association for Clinical Chemistry.