Clinical Chemistry
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Clinical Chemistry 20: 1138-1140, 1974;
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Clinical Chemistry, Vol 20, 1138-1140, Copyright © 1974 by the American Association for Clinical Chemistry

Evaluation of a Solubility Test Kit and an Automated Machine for Detecting Hemoglobin S

Sylvia M. Wilson 1 and Robert M. Schmidt 1

1 Hematology Division, Center for Disease Control, Public Health Service, U. S. Department of DHEW, Atlanta, Ga. 30333.

A solubility test kit (Sicklequik) and an instrument (SCAT Screener) designed to semiautomate the reading of the solubility test for the detection of hemoglobin S were evaluated for accuracy, precision, and specificity. Two hundred blood samples from persons with normal and variant hemoglobins were tested. Results were satisfactory for the test kit. However, the instrument gave incorrect results for 7% of the samples tested for hemoglobin S.


Key Words: Sicklequik • SCAT Screener • sickle cell anemia

Submitted on May 13, 1974
Accepted on June 6, 1974






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Copyright © 1974 by the American Association for Clinical Chemistry.