Clinical Chemistry
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Clinical Chemistry 20: 1155-1158, 1974;
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Clinical Chemistry, Vol 20, 1155-1158, Copyright © 1974 by the American Association for Clinical Chemistry

Values for Urinary Excretion of D-Glucaric Acid by Normal Individuals

James March 1, William J. Turner 1, Josette Shanley 1, and John Field 1

1 Research Division, Central Islip State Hospital, Central Islip, N. Y. 11722.

The urinary excretion of D-glucaric acid reflects the activity of hepatic enzymes that hydroxylate and detoxify many substances foreign to the body. We measured it in 38 healthy unmedicated males (ages, 3 to 90 years; weights 11.8 to 136 kg) and in 15 females (ages, 10 to 80). The males, regardless of age or weight, excreted 56.1 ± 15.7 (SD) nmol of D-glucaric acid per milligram of creatinine. A "standard man" would excrete 98 µmol of this compound per day, in agreement with observations by other workers. We infer that the normal hydroxylating activity of the liver is a direct function of body cell mass.


Key Words: 1,4-D-glucarolactone • creatinine • hepatic enzymes • detoxification • body cell mass • oxidoreductases

Submitted on April 28, 1974
Accepted on June 17, 1974






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Copyright © 1974 by the American Association for Clinical Chemistry.