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Clinical Chemistry 20: 1199-1203, 1974;
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Clinical Chemistry, Vol 20, 1199-1203, Copyright © 1974 by the American Association for Clinical Chemistry

Determination of Copper in Plasma and Serum by Use of a Microsampling Cup in Atomic Absorption Spectrometry

Arthur F. Ward 1, Douglas G. Mitchell 1, Murray Kahl 1, and Kenneth M. Aldous 1

1 Division of Laboratories and Research, New York State Department of Health, Albany, N. Y. 12201.

A microsampling cup procedure is described for rapid, precise determination of copper in plasma. Conventional Delves-cup atomic absorption spectrometry does not yield usable copper signals with blood plasma samples. Analytical sensitivity was improved 11-fold by use of cups fitted with an axial hole, a triangular cup-holding loop, and a smaller-bore absorption tube. The modified procedure yields relative standard deviations of 4-6% at the level of 95 µg of copper per deciliter. Analysis of 100 samples of blood plasma by both the microsampling cup procedure and a solvent-extraction atomic absorption procedure showed no significant difference between the two sets of data (P <.02).


Key Words: trace-element determination • comparison with flame absorption spectrophotometry • diagnostic aid

Submitted on May 6, 1974
Accepted on July 2, 1974






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Copyright © 1974 by the American Association for Clinical Chemistry.