Clinical Chemistry
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Clinical Chemistry 20: 1222-1226, 1974;
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Clinical Chemistry, Vol 20, 1222-1226, Copyright © 1974 by the American Association for Clinical Chemistry

Possible Interference by Chlordiazepoxide or Its Metabolites with Some Clinical Chemical Procedures

Herbert E. Spiegel 1, Hilda Sunico 1, and Darlene Scarince 1

1 Clinical Biochemistry Laboratory, Research Division, Hoffmann-La Roche, Inc., Nutley, N.J. 07110.

We examined the effect on some clinical chemical assays of adding chlordiazepoxide or its two metabolites, the lactam and the N-desmethylchlordiazepoxide, to serum or urine. We also examined the effect on urinary steroid values of administering the drug for as long as 20 days. The drug, in 10-fold the expected concentrations in blood, or its metabolites, in 200-fold the expected concentration in blood, had no significant effect on serum values for aspartate aminotransferase or alkaline phosphatase activities, values for bilirubin, albumin, or total protein, or on the electrophoretic pattern for serum proteins. Although values for urinary 17-hydroxycorticosteroids were slightly increased in addition experiments, we saw no effect of actual administration of the drug on values for either 17-hydroxycorticosteroids or 17-ketosteroids in urine.


Key Words: demoxepam • N-desmethylchlordiazepoxide • Librium • "kit" methods

Submitted on January 25, 1974
Accepted on May 15, 1974






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Copyright © 1974 by the American Association for Clinical Chemistry.