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Clinical Chemistry 20: 1229-1230, 1974;
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Clinical Chemistry, Vol 20, 1229-1230, Copyright © 1974 by the American Association for Clinical Chemistry

Increased beta-N-Acetyl-Glucosaminidase Activity in Diabetes Mellitus

Francesco Belfiore 1, Luigi Lo Vecchio 1, Elena Napoli 1, and Vito Borzi 1

1 The I Clinica Medica dell’Università di Catania, Ospedale Garibaldi, 95123 Catania, Italy.

In 45 diabetics the 24-h urinary excretion of beta-N-acetylglucosaminidase (E.C. 3.2.1.30) was increased by 40% (P < 0.05) compared to 35 control subjects. The enzyme excretion was correlated with glycemia (r = 0.58, P < 0.001), being little changed in diabetics with blood glucose concentrations of less than 200 mg/dl, and markedly elevated (+ 123%, P < 0.001) in those whose blood glucose was greater than 200 mg/dl. The rate of diuresis seemed to have no effect. These data indicate that the enhanced activity previously described in sera of diabetics for beta-N-acetyl-glucosaminidase (as well as for other lysosomal enzymes) cannot be attributed to impairment of renal excretion, and support the hypothesis that in diabetes there is an "activation" of lysosomal enzymes in tissues that causes an increase in their activity in serum and, consequently, in urine.

Submitted on May 13, 1974
Accepted on June 6, 1974






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Copyright © 1974 by the American Association for Clinical Chemistry.