Clinical Chemistry
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Clinical Chemistry 21: 98-103, 1975;
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Clinical Chemistry, Vol 21, 98-103, Copyright © 1975 by the American Association for Clinical Chemistry

Organic Nitrogen-Selective Detector Used in GasChromatographic Determination of Some Anticonvulsant and Barbiturate Drugs in Plasma and Tissues

Patrick A. Toseland 1, Michael Albani 1, and Franz D. Gauchel 1

1 Department of Clinical Chemistry, Guy's Hospital, London, SE1-9RT, England.

The specific nitrogen flame-ionization detector was used for the rapid simultaneous determination of eight anticonvulsant drugs and one drug metabolite in plasma and for three of the drugs in tissues. The system of analysis allows the occasional rapid estimation of barbiturate in plasma. No derivative formation is required and the whole range of drugs can be determined in a single diethyl ether extract of plasma in about 20 min.

Submitted on July 23, 1974
Accepted on October 16, 1974






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Copyright © 1975 by the American Association for Clinical Chemistry.