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Clinical Chemistry 21: 1774-1776, 1975;
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Clinical Chemistry, Vol 21, 1774-1776, Copyright © 1975 by the American Association for Clinical Chemistry

Plasma Theophylline Concentrations Measured by High-Pressure Liquid Chromatography

Daniel S. Sitar 1, Kenneth M. Piafsky 1, Robert E. Rangno 1, and Richard I. Ogilvie 1

1 Clinical Pharmacology Division, Montreal General Hospital, Montreal, Quebec H3G 1A4; and Departments of Medicine and Pharmacology and Therapeutics, McGill University, Montreal, Quebec, Canada.

We present a specific, sensitive high-pressure liquidchromatographic assay for theophylline in plasma. Only 0.5 ml of plasma is required for each determination, and the lower limit of detection by this method is 0.1 mg/ liter. Other xanthines and their metabolites do not interfere. This method is suitable for use in studying the pharmacokinetics of this drug in infants and children, from whom only small volumes of blood are available.


Key Words: pediatric chemistry

Submitted on April 14, 1975
Accepted on August 22, 1975






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Copyright © 1975 by the American Association for Clinical Chemistry.