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Clinical Chemistry 21: 1801-1803, 1975;
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Clinical Chemistry, Vol 21, 1801-1803, Copyright © 1975 by the American Association for Clinical Chemistry

Negligible Interference by Spironolactone and Prednisone in Digoxin Radioimmunoassay

Richard Ravel 1

1 Nuclear Medicine Section, Department of Pathology, St. Francis Hospital, Miami Beach, Fla. 33141.

Spironolactone and prednisone reportedly cause measurable values for apparent digoxin, even when none is present. Effects of these medications were evaluated with 125l-labeled digoxin kits from five different manufacturers. Values obtained for apparent digoxin were either negligible or not sufficiently great to be clinically significant, regardless of kit methodology or manufacturer.


Key Words: "kit" methods

Submitted on June 13, 1975
Accepted on August 4, 1975






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Copyright © 1975 by the American Association for Clinical Chemistry.