Clinical Chemistry
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Clinical Chemistry 21: 1873-1877, 1975;
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Clinical Chemistry, Vol 21, 1873-1877, Copyright © 1975 by the American Association for Clinical Chemistry

Current Concepts of "Normal Values," "Reference Values," and "Discrimination Values" in Clinical Chemistry

F. William Sunderman Jr. 1

1 Department of Laboratory Medicine, University of Connecticut School of Medicine, Farmington, Conn. 06032.

The term "normal values" is seriously afflicted by sylleptic ambiguities and conceptual problems, and it is gradually being discarded from the lexicon of clinical chemistry. The neutral term "reference values" is preferable on semantic and scientific grounds, and its use in clinical chemistry is rapidly gaining acceptance. The term "discrimination value" has been added to the lexicon of clinical chemistry. Use of the "discrimination value" for the results of a laboratory test in a specified clinical situation provides the optimal discrimination between the "healthy" and the "diseased," or between "those who need not be investigated further" and "those who do."


Key Words: biometry • statistics • decision-making

Submitted on August 25, 1975




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Copyright © 1975 by the American Association for Clinical Chemistry.