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Clinical Chemistry 21: 1887-1891, 1975;
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Clinical Chemistry, Vol 21, 1887-1891, Copyright © 1975 by the American Association for Clinical Chemistry

Diagnosis of Type III Hyperlipoproteinemia by Chromatography of Plasma Lipoproteins on Columns Containing Agarose

James Shepherd 1, Christopher J. Packard 1, Frances J. Dryburgh 1, and Jane L. H. C. Third 1

1 University Departments of Pathological Biochemistry1 and Medical Cardiology,2 Royal Infirmary, Glasgow G4 OSF, Scotland.

Agarose column chromatography has been used to separate plasma lipoproteins into very-low-density lipoproteins (VLDL), low-density lipoproteins (LDL) and high-density lipoproteins (HDL). Applied to the diagnosis of primary type III hyperlipoproteinemia, the procedure is capable of demonstrating three characteristic and specific changes from normality in the elution pattern of lipoproteins from patients with this condition. In the type III profile there is (a) incomplete separation of VLDL from putative LDL material, (b) early elution of the type III LDL with respect to a normal LDL marker, and (c) relative deficiency of type III LDL with elution characteristics of normal LDL. We advocate the use of this method in the diagnosis of type III hyperlipoproteinemia.

Submitted on July 21, 1975






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Copyright © 1975 by the American Association for Clinical Chemistry.