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Clinical Chemistry 21: 1918-1921, 1975;
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Clinical Chemistry, Vol 21, 1918-1921, Copyright © 1975 by the American Association for Clinical Chemistry

Gas-Chromatographic Analysis for Cocaine in Human Plasma, with Use of a Nitrogen Detector

Peter I. Jatlow 1 and David N. Bailey 1

1 Department of Laboratory Medicine, Yale University School of Medicine, New Haven, Conn. 06510.

We describe a procedure for measuring the concentration of cocaine in plasma by gas chromatography, with use of a nitrogen detector. The procedure was tested on patients receiving intranasal cocaine for topical anesthesia. The propyl ester of benzoylecgonine is used as an internal standard. The lower limit of sensitivity of the procedure is 5-10 µg of cocaine per liter of plasma. The coefficients of variation are 5.3% and 3.0% for concentrations of 50 and 100 µg/liter, respectively.


Key Words: cocaine in urine • drug assay • preparation ofn-propyl ester of benzoylecgonine • "alkali flame" detector

Submitted on July 21, 1975




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R. E. Mittleman and C. V. Wetli
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Is Cocaine a Sympathetic Stimulant During General Anesthesia?
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C Van Dyke, P Jatlow, J Ungerer, P. Barash, and R Byck
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Copyright © 1975 by the American Association for Clinical Chemistry.