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Clinical Chemistry 21: 1956-1960, 1975;
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Clinical Chemistry, Vol 21, 1956-1960, Copyright © 1975 by the American Association for Clinical Chemistry

Gas-Chromatographic Measurement of Codeine and Norcodeine in Human Plasma

Mary K. Brunson 1 and J. Frank Nash 1

1 Analytical Development Department, Lilly Research Laboratories, Indianapolis, Ind. 46206.

A gas-chromatographic method is described for determination of codeine and norcodeine in human plasma. The method is specific, sensitive, and precise. It was developed for use in bioavailability studies of therapeutic doses of codeine sulfate. After ingestion of a 60-mg codeine sulfate tablet, mean peak codeine concentration in plasma was 107 µg/liter at 1.0 hour. No measurable concentration of norcodeine was found in the plasma by this method.

Submitted on June 6, 1975






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Copyright © 1975 by the American Association for Clinical Chemistry.