Clinical Chemistry
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Clinical Chemistry 21: 1976-1979, 1975;
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Clinical Chemistry, Vol 21, 1976-1979, Copyright © 1975 by the American Association for Clinical Chemistry

Fluorometric Screening Method for Detecting Benzodiazepines in Blood and Urine

James C. Valentour 1, Joseph R. Monforte 2, Beverly Lorenzo 1, and Irving Sunshine 1

1 Cuyahoga County Coroner's Office, 2121 Adelbert Road, Cleveland, Ohio 44106; and the Department of Pathology, School of Medicine, Case Western Reserve University, Cleveland, Ohio 44106.
2 Wayne County Medical Examiner's Office, 400 E. Lafayette St., Detroit, Mich. 48226.

We report a fluorometric method for detecting diazepam, chlordiazepoxide, oxazepam, chlorazepate, and (or) their major metabolites in blood, urine, or gastric contents at low therapeutic concentrations. The drugs are first hydrolyzed to their respective benzophenones and converted to highly fluorescent 9-acridanones. Total benzodiazepines (parent plus metabolites) in blood and gastric contents are semiquantitatively evaluated and compared to results of gas-chromatographic determinations.

Submitted on January 10, 1975
Accepted on October 1, 1975






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Copyright © 1975 by the American Association for Clinical Chemistry.