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Clinical Chemistry 21: 190-194, 1975;
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Clinical Chemistry, Vol 21, 190-194, Copyright © 1975 by the American Association for Clinical Chemistry

Comparison of Methods for Calculating Serum Osmolality from Chemical Concentrations, and the Prognostic Value of Such Calculations

William V. Dorwart 1 and Leslie Chalmers 1

1 William Pepper Laboratory, Division of Chemistry, Hospital of the University of Pennsylvania, Philadelphia, Pa. 19104.

Sodium, potassium, glucose, blood urea nitrogen, and osmolality were determined for 715 hospital-patient sera. The chemical concentrations were used to calculate osmolalities according to 13 different methods taken from the literature. The goodness of the comparison between calculated and measured osmolality was quite similar for several of the better methods. The agreement was unimproved when molal chemical concentrations were used instead of molar values. The difference between measured and calculated osmolality was unrelated to whether a patient was discharged from the hospital after a short or long period or ultimately died. The equation we found to yield the most accurately calculated osmolalities is

Submitted on August 23, 1974
Accepted on November 5, 1974




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Copyright © 1975 by the American Association for Clinical Chemistry.