Clinical Chemistry
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Clinical Chemistry 21: 264-267, 1975;
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Clinical Chemistry, Vol 21, 264-267, Copyright © 1975 by the American Association for Clinical Chemistry

Evaluation of the Corning 940 Calcium Titrator for Use with Serum and Urine

Earl B. Weissman 1, Desider A. Pragay 2, and Charles Bishop 3

1 Postdoctoral Fellow, Biochemistry Laboratory, Buffalo General Hospital. Present address: Laboratory Procedures, Woodland Hills, Calif. 91364.
2 Erie County Laboratories, 462 Grider St., Buffalo, N. Y. 14215.
3 Reprint requests should be sent to Dr. Bishop, Buffalo General Hospital, 100 High St., Buffalo, N. Y. 14203.

The Corning 940 Titrator, which measures total calcium concentration by titration with [ethylenebis(oxyethylenenitrilo)]tetraacetic acid, was evaluated for use in a hospital laboratory. Calcium values for patients' sera were about 0.3 mg/dl lower as measured with the Titrator than with the Technicon SMA 12/60 continuous-flow analyzer. A similar bias was evident when the results with the Titrator were compared with those from atomic absorption spectrophotometry. Agreement was better in the low range and worse in the high range. Within-day and between-day coefficients of variation on the Titrator were about 1.5% and 2.5%, respectively. We saw no interference from magnesium, phosphorus, bilirubin, or in the presence of lipemia. At extremely increased hemoglobin concentrations (500 mg/dl), there is a 5% inhibition. Titrator results for patients' urine samples correlated closely (n = 0.999) with those obtained with the SMA 12/60.

Submitted on July 26, 1974
Accepted on December 2, 1974






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Copyright © 1975 by the American Association for Clinical Chemistry.