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Clinical Chemistry 21: 321-324, 1975;
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Clinical Chemistry, Vol 21, 321-324, Copyright © 1975 by the American Association for Clinical Chemistry

The Impact of Laboratory Error on the Normal Range: A Bayesian Model

R. D. Krause 1, V. D. Anand 1, H. D. Gruemer 1, and T. A. Willke 1

1 Division of Clinical Chemistry, Department of Pathology (R. D. K., V. D. A., and H.-D. G.) and the Department of Statistics (T. A. W.), Ohio State University, Columbus, Ohio 43210.

Interpretation of clinical laboratory results, aside from clinical considerations, is based on the probability of the result being within a given normal range. This probability is influenced by the degree of error inherent in the analytical method. It would be advantageous to assign a more definite probability to the result of the measurement by combining the error distribution of the result around the true value and the distribution of the healthy population that serves as a reference. Bayesian statistics permits the revision of this prior information into a single probability.


Key Words: statistics • error distribution • probability statements • precision • normal values • quality control

Submitted on June 17, 1974
Accepted on December 6, 1974






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Copyright © 1975 by the American Association for Clinical Chemistry.