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Clinical Chemistry 21: 402-406, 1975;
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Clinical Chemistry, Vol 21, 402-406, Copyright © 1975 by the American Association for Clinical Chemistry

Effect of Albumin on Serum Digoxin Radioimmunoassays

David L. Voshall 1, Lynda Hunter 1, and Harold J. Grady 1

1 Pathology Department, Baptist Memorial Hospital, 6601 Rockhill Road, Kansas City, Mo. 64131.

The use of certain commercially available radioimmunoassay kits for measurement of digoxin results in errors in the determined digoxin concentration of patients when these kits are used according to manufacturers' directions. One factor that is, in part, responsible for these errors is a difference between standards and samples with respect to albumin concentration. Three of the four kits investigated showed a significant inverse relationship between the albumin concentration in the sample and the binding of radiolabeled digoxin by its antibody when the albumin concentration was varied over an extended range. It is apparent, however, that differences in albumin concentration do not completely explain the observed variations in the assay values.


Key Words: "kit" methods • analytical error • glycosides • drug assay

Submitted on June 5, 1974
Accepted on January 3, 1975






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Copyright © 1975 by the American Association for Clinical Chemistry.