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Clinical Chemistry, Vol 21, 558-561, Copyright © 1975 by the American Association for Clinical Chemistry
1 The Perkin-Elmer Corporation, Main Ave., Norwalk, Conn.
06856.
I describe a micro-scale method for determining lead in whole blood by utilizing a graphite furnace. Sample pretreatment consists of fivefold dilution with a dilute surfactant. The method is directly calibrated with lead standards prepared in dilute HNO3. To eliminate a small, nonspecific absorption signal from the blood matrix, simultaneous background correction is used. Interlaboratory comparison with a flame atomic absorption technique that requires extraction yielded high correlation (r = 0.98). Within-run precision (coefficient of variation) ranged from 2 to 4%. Lead in blood can be accurately measured in as little as 20 µl of blood, hence the method is suitable for routine laboratory use and for pediatric screening.
Submitted on January 10, 1975
Accepted on January 20, 1975
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