| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
Clinical Chemistry, Vol 21, 582-587, Copyright © 1975 by the American Association for Clinical Chemistry
1 Department of Medicine, Wayne State University, Detroit General Hospital, Grace Hospital, Detroit; the V. A. Hospital, Allen
Park; and the Department of Human Genetics, University of
Michigan, Ann Arbor, Mich..
Clinical similarities between patients with sickle cell anemia and zinc-deficient subjects suggested a secondary zinc deficiency in sickle cell anemia. Zinc was assayed in various biological fluids and tissues by atomic absorption spectrophotometry. Zinc in the plasma, erythrocytes, and hair was decreased and urinary zinc excretion was increased in anemia patients as compared to controls. Erythrocyte zinc and daily urinary zinc excretion were inversely correlated in the anemia patients (r = -.63, P < 0.05), suggesting that hyperzincuria may have caused zinc deficiency in these patients. Carbonic anhydrase, a zinc metalloenzyme, correlated significantly with erythrocyte zinc (r = +0.94, P < 0.001). Plasma RNase activity was significantly greater in anemia subjects than in controls. We administered zinc sulfate, 660 mg per day, orally, to seven men and two women with sickle cell anemia. Two 17-year-old males gained 5 cm and 7 cm in height during 49 and 42 weeks of zinc therapy, respectively. All but one patient gained weight (0.5 kg to 4.1 kg). Five of the males showed increased growth of pubic, axillary, facial, and body hair, and in one a leg ulcer healed in six weeks on zinc and in two others some benefit of zinc therapy on healing of ulcers was noted.
Submitted on October 2, 1974
Accepted on January 29, 1975
The following articles in journals at HighWire Press have cited this article:
|
|
 |
|
  I. Berthaut, G. Guignedoux, F. Kirsch-Noir, V. de Larouziere, C. Ravel, D. Bachir, F. Galacteros, P.-Y. Ancel, J.-M. Kunstmann, L. Levy, et al. Influence of sickle cell disease and treatment with hydroxyurea on sperm parameters and fertility of human males Haematologica, July 1, 2008; 93(7): 988 - 993. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. Kaler and R. Prasad Molecular cloning and functional characterization of novel zinc transporter rZip10 (Slc39a10) involved in zinc uptake across rat renal brush-border membrane Am J Physiol Renal Physiol, January 1, 2007; 292(1): F217 - F229. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. C Lukaski Low dietary zinc decreases erythrocyte carbonic anhydrase activities and impairs cardiorespiratory function in men during exercise Am. J. Clinical Nutrition, May 1, 2005; 81(5): 1045 - 1051. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. Rej Clinical Chemistry through Clinical Chemistry: A Journal Timeline Clin. Chem., December 1, 2004; 50(12): 2415 - 2458. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. A. Strand, S. K. Hollingshead, K. Julshamn, D. E. Briles, B. Blomberg, and H. Sommerfelt Effects of Zinc Deficiency and Pneumococcal Surface Protein A Immunization on Zinc Status and the Risk of Severe Infection in Mice Infect. Immun., April 1, 2003; 71(4): 2009 - 2013. [Abstract] [Full Text]
|
|
|
|
|
|
A. S Prasad Zinc deficiency in patients with sickle cell disease Am. J. Clinical Nutrition, February 1, 2002; 75(2): 181 - 182. [Full Text] [PDF]
|
|
|
|
|
|
B. S Zemel, D. A Kawchak, E. B Fung, K. Ohene-Frempong, and V. A Stallings Effect of zinc supplementation on growth and body composition in children with sickle cell disease Am. J. Clinical Nutrition, February 1, 2002; 75(2): 300 - 307. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Lerman-Sagie, M. Statter, and P. Lerman Low Erythrocyte Zinc Content in Acquired Aphasia With Convulsive Disorder (Landau-Kleffner Syndrome) J Child Neurol, January 1, 1987; 2(1): 28 - 30. [Abstract] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
