Clinical Chemistry
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Clinical Chemistry 21: 613-618, 1975;
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Clinical Chemistry, Vol 21, 613-618, Copyright © 1975 by the American Association for Clinical Chemistry

Retention of Fluoride with Time in Man

Herta Spencer 1, Dace Osis 1, and Emilie Wiatrowski 1

1 Metabolic Section, Veterans Administration Hospital, Hines, Ill. 60141.

Fluoride retention is high during fluoride supplementation and increases with increasing fluoride intake. When large amounts of fluoride were given for several months the retention of fluoride was about the same as in the initial phase of fluoride supplementation, whether the supplemental dose of fluoride was 10, 20, or 45 mg per day. The rapid return of the fluoride balance to control values after the high fluoride intake was discontinued indicates that there is not only a tendency for continued retention of fluoride during the high fluoride intake but also after large amounts of fluoride have already been retained.


Key Words: treatment of osteoporosis • excretlon of F - in urine and feces during prolonged high doses • F- balance

Submitted on February 1, 1975






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Copyright © 1975 by the American Association for Clinical Chemistry.