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Clinical Chemistry 21: 626-629, 1975;
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Clinical Chemistry, Vol 21, 626-629, Copyright © 1975 by the American Association for Clinical Chemistry

Determination of Cadmium in Blood and Urine by Graphite Furnace Atomic Absorption Spectrophotometry

Elizabeth F. Perry 1, S. Roy Koirtyohann 1, and H. Mitchell Perry Jr. 1

1 The Medical Service, Veterans Administration Hospital, and the Hypertension Division, Department of Medicine, Washington University School of Medicine, St. Louis, Mo. 63110 (E. F. P. and H. M. P.); and the Environmental Trace Substances Research Laboratory, University of Missouri, Columbia, Mo.

We describe a method for measuring quantities of cadmium in blood, plasma, and urine by using graphite furnace atomic absorption preceded by wet ashing. The method appears to be extremely accurate and reproducible (coefficient of variation is 7% for 2.8 µg/liter concentration), with a detection limit of 2 pg.


Key Words: metallothionein • hypertension • normal values

Submitted on December 9, 1974
Accepted on February 7, 1975




The following articles in journals at HighWire Press have cited this article:


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K. Ellis, D Vartsky, I Zanzi, S. Cohn, and S Yasumura
Cadmium: in vivo measurement in smokers and nonsmokers
Science, July 20, 1979; 205(4403): 323 - 325.
[Abstract] [PDF]


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Copyright © 1975 by the American Association for Clinical Chemistry.