Clinical Chemistry
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Clinical Chemistry 21: 860-863, 1975;
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Clinical Chemistry, Vol 21, 860-863, Copyright © 1975 by the American Association for Clinical Chemistry

Relative Usefulness of Measuring Polyamines in Serum, Plasma, and Urine as Biochemical Markers of Cancer

Diane H. Russell 1 and Shauna D. Russell 1

1 Department of Pharmacology, University of Arizona Medical Center, Tucson, Ariz. 85724

Serial samples of plasma and serum were collected in the morning and afternoon from cancer patients, along with 24-h urine specimens. Values for serum and plasma samples taken at the same time from the same patient differed little, suggesting that either procedure is acceptable for polyamine analysis. Increases in concentrations of putrescine and spermidine in serum and plasma correlate well with such increases in 24-h urine samples. Spermidine concentrations in sera were consistently about 10-fold lower than corresponding urine values. Putrescine concentrations were 10to 100-fold different. The variation in putrescine values may be due to its more active metabolism by diamine oxidase, an enzyme known to be present in serum. Concentrations of polyamines in serum and urine increased in response to effective chemotherapy.


Key Words: putrescine, cadaverine, spermidine, spermine • cation-exchange chromatography

Submitted on January 15, 1975
Accepted on March 24, 1975




The following articles in journals at HighWire Press have cited this article:


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 Arch DermatolHome page
M. S. Proctor, D. I. Wilkinson, E. K. Orenberg, and E. M. Farber
Lowered Cutaneous and Urinary Levels of Polyamines With Clinical Improvement in Treated Psoriasis
Arch Dermatol, August 1, 1979; 115(8): 945 - 949.
[Abstract] [PDF]


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Copyright © 1975 by the American Association for Clinical Chemistry.