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Clinical Chemistry 21: 888-891, 1975;
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Clinical Chemistry, Vol 21, 888-891, Copyright © 1975 by the American Association for Clinical Chemistry

Use of High-Resolution Open Tubular Glass Capillary Columns to Separate Acidic Metabolites in Urine

Brian A. Knights 1, Mary Legendre 2, John L. Laseter 2, and James S. Storer 3

1 Department of Biological Sciences, University of New Orleans, New Orleans, La. 70211.On leave from Department of Botany, University of Glasgow, Glasgow, Scotland.
2 Department of Biological Sciences, University of New Orleans, New Orleans, La. 70211.
3 Department of Pediatrics, Louisiana State University School of Medicine, New Orleans, La. 70112.

We used high-resolution glass capillary columns to study the trimethylsilyl derivatives of some acidic metabolites found in pooled urine specimens from control and postpartum subjects. About 30 compounds were identified by gas chromatography—mass spectrometry—computer techniques. In general, open tubular capillary columns effect better resolution of trimethylsilyl derivatives of organic acids than do conventional packed columns. GE SE-30 proved to be a good general-purpose stationary phase, whereas OV-17 offered certain advantages in resolving aromatic acid components.


Key Words: gas chromatography—mass spectrometry—computer combination

Submitted on November 8, 1974
Accepted on March 10, 1975






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Copyright © 1975 by the American Association for Clinical Chemistry.