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Clinical Chemistry 21: 1059-1062, 1975;
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Clinical Chemistry, Vol 21, 1059-1062, Copyright © 1975 by the American Association for Clinical Chemistry

A Radioimmunoassay for Isoniazid

Robert Schwenk 1, Kenneth Kelly 1, Kam S. Tse 1, and Alec H. Sehon 1

1 MRC Group for Allergy Research, Departments of Immunology and Medicine, Faculty of Medicine, University of Manitoba, Winnipeg, Manitoba, Canada, R3E OW3.

A sensitive radioimmunoassay is described, for measuring isoniazid in therapeutic and subtherapeutic concentrations. This radioimmunoassay was used in an exploratory clinical study to measure, as a function of time, the concentration of this drug in plasma of patients receiving isoniazid therapy.


Key Words: toxicology • monitoring drugs in sera • therapy for tuberculosis • cross reactivity

Submitted on November 25, 1974
Accepted on April 1, 1975






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Copyright © 1975 by the American Association for Clinical Chemistry.