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Clinical Chemistry 21: 1072-1076, 1975;
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Clinical Chemistry, Vol 21, 1072-1076, Copyright © 1975 by the American Association for Clinical Chemistry

Comparison of Electrophoresis on Citrate Agar, Cellulose Acetate, or Starch for Hemoglobin Identification

Edward J. Hicks 1 and Blossie J. Hughes 1

1 Department of Clinical Pathology, Indiana University Medical Center, Indianapolis, Ind. 46202.

We compare and discuss three electrophoretic methods for identifying hemoglobins S, A, C, F, and D or G. Electrophoresis on citrate agar gel was more sensitive than electrophoresis on cellulose acetate for detecting hemoglobins S and F, a fundamental consideration in designing cord-blood screening programs for detecting hemoglobin S carriers. Electrophoresis on starch gel is evidently an acceptable method for subtyping hemoglobins AA, CC, AS, SS, AC, and SC, and is more sensitive than cellulose acetate for identifying hemoglobin A1A2. Costs for the citrate agar gel, cellulose acetate, and starch gel procedures are presented.


Key Words: intermethod comparison • analytical costs • screening • isoelectric focusing • sickle cell anemia

Submitted on January 6, 1975
Accepted on April 8, 1975




The following articles in journals at HighWire Press have cited this article:


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 ScienceHome page
W. Winter and J Yodh
Interaction of human hemoglobin and its variants with agar
Science, July 8, 1983; 221(4606): 175 - 178.
[Abstract] [PDF]


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Copyright © 1975 by the American Association for Clinical Chemistry.