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Clinical Chemistry 21: 1192-1200, 1975;
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Clinical Chemistry, Vol 21, 1192-1200, Copyright © 1975 by the American Association for Clinical Chemistry

Applications of a Vidicon Spectrometer to Analytical Problems in Clinical Chemistry

Harry L. Pardue 1, Alan E. McDowell 1, Douglas M. Fast 1, and Michael J. Milano 1

1 Department of Chemistry, Purdue University, West Lafayette, Ind. 47907.

This report discusses characteristics of a custom-designed vidicon spectrometer and evaluates its applicability to several clinical analysis problems. Data show that the vidicon detector response is linear with intensity over about four orders of magnitude and that the uncertainty in absorbance measurements can approach 0.001 absorbance units in the range from 0 to 2 absorbance units. Applications include the enzymatic determination of glucose, the determination of lactate dehydrogenase, and determinations of barbital, chlordiazepoxide, and glutethimide. Capabilities of the instrument system for first-derivative spectroscopy are also discussed. The discussion includes a critical evaluation of the potential advantages and limitations of the concept.


Key Words: determination of glucose and of lactate dehydrogenase activity • drug assay • derivative spectroscopy • simultaneous multicomponent analyses • multiwavelength detection of analytes • centrifugal analyzer • liquid chromatography

Submitted on April 9, 1975
Accepted on May 5, 1975






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Copyright © 1975 by the American Association for Clinical Chemistry.