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Clinical Chemistry 21: 1288-1293, 1975;
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Clinical Chemistry, Vol 21, 1288-1293, Copyright © 1975 by the American Association for Clinical Chemistry

Coagulation-Time Determination with Automatic Multivariable Analysis, by Use of a Miniature Centrifugal Fast Analyzer

W. D. Bostick 1, M. L. Bauer 1, J. M. Morton 1, and C. A. Burtis 1

1 Oak Ridge National Laboratory,1 Oak Ridge, Tenn. 37830.

Use of a miniature Centrifugal Fast Analyzer for the parallel photometric monitoring of the coagulation process is shown to have a number of advantages. These include a choice of optical modes, virtually simultaneous initiation and observation of the coagulation process for a number of patient-plasma samples and an on-board control sample, small sample and reagent volume requirements, and automatic determination of a number of diagnostically useful variables (including relative fibrinogen content) from the data recorded in a single run. Also, the system is shown to give results that correlate well with those obtained by conventional techniques for determination of prothrombin time.


Key Words: prothrombin-time determination • fibrinogen measurement • parallel analysis • photoelectric coagulation detector • pediatric application • the clotting process • rate of fibrin formation

Submitted on April 16, 1975
Accepted on May 31, 1975






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Copyright © 1975 by the American Association for Clinical Chemistry.