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Clinical Chemistry 21: 1297-1304, 1975;
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Clinical Chemistry, Vol 21, 1297-1304, Copyright © 1975 by the American Association for Clinical Chemistry

A Flow-System Multiangle Light-Scattering Instrument for Cell Characterization

G. C. Salzman 1, J. M. Crowell 1, C. A. Goad 1, K. M. Hansen 1, R. D. Hiebert 1, P. M. LaBauve 1, J. C. Martin 1, M. L. Ingram 1, and P. F. Mullaney 1

1 Biophysics and Instrumentation Group, Los Alamos Scientific Laboratory, University of California, Los Alamos, N. Mex. 87544.

A flow-system cell-analysis instrument is described in which cells from a heterogeneous population are characterized by their light-scatter patterns alone. As the cells pass at high speed through a focused helium/neon laser beam, the scatter pattern from each cell is sampled simultaneously at up to 32 angles between 0° and 30° with respect to the laser beam axis, and the scatter pattern for each cell is transferred to a computer. A mathematical clustering algorithm is used to determine the number of classes into which the cells can be divided, and a linear separation algorithm is used to find the boundaries between the classes. Preliminary results on exfoliated cells from gynecological specimens are presented. This technique may be useful for automated prescreening of gynecological specimens.


Key Words: laser • categorization of cells from vagina and cervix • cancer screening

Submitted on April 16, 1975
Accepted on May 21, 1975




The following articles in journals at HighWire Press have cited this article:


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P. Horan and L. Wheeless Jr
Quantitative single cell analysis and sorting
Science, October 14, 1977; 198(4313): 149 - 157.
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