Clinical Chemistry
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Clinical Chemistry 22: 53-56, 1976;
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Clinical Chemistry, Vol 22, 53-56, Copyright © 1976 by American Association for Clinical Chemistry

Measuring picogram amounts of aluminum in biological tissue by flameless atomic absorption analysis of a chelate

GR LeGendre and AC Alfrey

We describe a flameless atomic absorption method for aluminum determination in ethylenediaminetetraacetate extracts of biological tissues. Picogram quantities can be detected, and the technique appears to be more sensitive than other methods of aluminum determination used for biological samples. The extraction simplifies the method and virtually eliminates contamination with extraneous aluminum during the analysis. The extraction method might be useful for separating various other trace elements from biological tissues before analysis.


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K. I. Bolla, G. Briefel, D. Spector, B. S. Schwartz, L. Wieler, J. Herron, and L. Gimenez
Neurocognitive Effects of Aluminum
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J. A. Robertson, I. B. Salusky, W. G. Goodman, K. C. Norris, and J. W. Coburn
Sucralfate, Intestinal Aluminum Absorption, and Aluminum Toxicity in a Patient on Dialysis
Ann Intern Med, July 15, 1989; 111(2): 179 - 181.
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G. L. Klein, A. B. Sedman, M. B. Heyman, G. Marathe, H. A. Battifora, J. L. Worrall, R. L. Horst, G. J. Brewer, N. L. Miller, and A. C. Alfrey
Hepatic Abnormalities Associated with Aluminum Loading in Piglets
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M. B. Heyman, G. L. Klein, A. Wong, R. R. Recker, J. B. Tyrrell, A. C. Alfrey, D. J. Sherrard, and D. C. Hohn
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W. T. Longstreth Jr, L. Rosenstock, and N. J. Heyer
Potroom Palsy? Neurologic Disorder in Three Aluminum Smelter Workers
Arch Intern Med, November 1, 1985; 145(11): 1972 - 1975.
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D. S. MILLINER, H. G. NEBEKER, S. M. OTT, D. L. ANDRESS, D. J. SHERRARD, A. C. ALFREY, E. A. SLATOPOLSKY, and J. W. COBURN
Use of the Deferoxamine Infusion Test in the Diagnosis of Aluminum-Related Osteodystrophy
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S. M. OTT, N. A. MALONEY, G. L. KLEIN, A. C. ALFREY, M. E. AMENT, J. W. COBURN, and D. J. SHERRARD
Aluminum Is Associated with Low Bone Formation in Patients Receiving Chronic Parenteral Nutrition
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A. B. HODSMAN, D. J. SHERRARD, E. G. C. WONG, A. S. BRICKMAN, D. B. N. LEE, A. C. ALFREY, F. R. SINGER, A. W. NORMAN, and J. W. COBURN
Vitamin-D-Resistant Osteomalacia in Hemodialysis Patients Lacking Secondary Hyperparathyroidism
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Copyright © 1976 by the American Association for Clinical Chemistry.