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Clinical Chemistry 22: 1697-1701, 1976;
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Clinical Chemistry, Vol 22, 1697-1701, Copyright © 1976 by American Association for Clinical Chemistry

Gas-chromatographic analysis for therapeutic concentration of imipramine and disipramine in plasma, with use of a nitrogen detector

DN Bailey and PI Jatlow

We describe a method for the simultaneous gas-chromatographic analysis of imipramine and desipramine (the active N-desmethyl metabolite) at therapeutic concentrations in human plasma, with use of a nitrogen detector. Imipramine is measured as the unchanged base and desipramine as its N-tribluoroacetyl derivative. Promazine is the internal standard. The lower limit of sensitivity is 5 mug/liter for each drug, and the within-day coefficients of variation for the determination of imipramine and desipramine, respectively, are 6.0% and 3.3%. We measured concentrations of these drugs both in patients receiving therapeutic doses of imipramine and in those who had ingested an overdose.


The following articles in journals at HighWire Press have cited this article:


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 Hum Exp ToxicolHome page
W.P. Tormey, H. Crosse, and A. Pierce
Chemical Toxicology for the Coroner
Human and Experimental Toxicology, September 1, 1989; 8(5): 375 - 379.
[Abstract] [PDF]

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 Hum Exp ToxicolHome page
A.H. Stead and A.C. Moffat
A Collection of Therapeutic, Toxic and Fatal Blood Drug Concentrations in Man
Human and Experimental Toxicology, January 1, 1983; 2(3): 437 - 464.
[Abstract] [PDF]


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Copyright © 1976 by the American Association for Clinical Chemistry.