Clinical Chemistry
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Clinical Chemistry 22: 1903-1906, 1976;
This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Adams, R.
Right arrow Articles by Schmidt, G.
Right arrow Search for Related Content
PubMed
Right arrow Articles by Adams, R.
Right arrow Articles by Schmidt, G.

Clinical Chemistry, Vol 22, 1903-1906, Copyright © 1976 by American Association for Clinical Chemistry

More sensitive high-pressure liquid-chromatographic determiantion of theophylline in serum

RF Adams, FL Vandemark and GJ Schmidt

We present procedures for determining theophylline in 50 mul of serum. The drug is extracted into a small volume of solvent that contains an internal standard, 8-chlorotheophylline. The extract is Analyzed by isocratic reversedphase chromatography, with measurement of eluted theophylline at 273 nm. Day-to-day reproducibility within 5% is attainable for the concentration range 5--20 mg/liter. Other xanthines and related metabolites do not interfere. Sensitivity is 1 mg/liter. The correlation coefficient, when results by a spectrophotometric procedure were compared, was 0.989. Amobarbital, secobarbital, phenobarbital, and diphenylhydantoin do not interfere. Total analysis time for a single sample is 15 min.


The following articles in journals at HighWire Press have cited this article:


Home page
 Arch Gen PsychiatryHome page
D. S. Charney, G. R. Heninger, and P. I. Jatlow
Increased Anxiogenic Effects of Caffeine in Panic Disorders
Arch Gen Psychiatry, March 1, 1985; 42(3): 233 - 243.
[Abstract] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 1976 by the American Association for Clinical Chemistry.