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Clinical Chemistry 22: 1912-1914, 1976;
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Clinical Chemistry, Vol 22, 1912-1914, Copyright © 1976 by American Association for Clinical Chemistry

Improved thyroxine radioimmunoassay, for filter paper discs saturated with dried blood

ML Mitchell

I describe an improved procedure for estimating thyroxine in dried blood on 0.32-cm filter paper discs, by radioimmunoassay. A weak anion- exchange resin is used to separate free and antibody-bound radiothyroxine and, by measuring the resin-bound 125I-labeled thyroxine rather than the supernatant radioactivity, a tedious and cumbersome step is eliminated. The unique properties of the resin permit considerable latitude in the experimental conditions, in contrast with charcoal, without compromising sensitivity or precision. There is excellent correlation between thyroxine values obtained from discs and those of the corresponding plasmas. Application of this procedure for large-scale screening of newborns has proved to be highly successful in identifying thyroid insufficiency in several babies before clinical signs were apparent.


The following articles in journals at HighWire Press have cited this article:


Home page
 NEJMHome page
J. E. Haddow, G. E. Palomaki, W. C. Allan, J. R. Williams, G. J. Knight, J. Gagnon, C. E. O'Heir, M. L. Mitchell, R. J. Hermos, S. E. Waisbren, et al.
Maternal Thyroid Deficiency during Pregnancy and Subsequent Neuropsychological Development of the Child
N. Engl. J. Med., August 19, 1999; 341(8): 549 - 555.
[Abstract] [Full Text] [PDF]

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 Arch Pediatr Adolesc MedHome page
C. M. Gordon, D. H. Rowitch, M. L. Mitchell, and I. S. Kohane
Topical Iodine and Neonatal Hypothyroidism
Arch Pediatr Adolesc Med, December 1, 1995; 149(12): 1336 - 1339.
[Abstract] [PDF]

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 JAMAHome page
M. L. Mitchell, P. R. Larsen, H. L. Levy, A. J. E. Bennett, and M. A. Madoff
Screening for Congenital Hypothyroidism: Results in the Newborn Population of New England
JAMA, June 2, 1978; 239(22): 2348 - 2351.
[Abstract] [PDF]


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Copyright © 1976 by the American Association for Clinical Chemistry.