Clinical Chemistry AACC Online Job Center
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Clinical Chemistry 22: 1982-1985, 1976;
This Article
Right arrow Full Text (PDF)
Right arrow Submit an electronic Letter to
the Editor about this paper
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Ritchie, R.
Right arrow Articles by Smith, R
Right arrow Search for Related Content
PubMed
Right arrow Articles by Ritchie, R.
Right arrow Articles by Smith, R

Clinical Chemistry, Vol 22, 1982-1985, Copyright © 1976 by American Association for Clinical Chemistry

Immunofixation. III. Application to the study of monoclonal proteins

RF Ritchie and R Smith

We have shown how immunofixation can be successfully used to study proteins exhibiting electrophoretic polymorphism. An analogous situation is seen in the disorders of the immune system that result in the production of variable quantitites of homogeneous immunoglobulins. Immunoelectrophroesis has been heavily used--sometimes unsuccessfully because of poor resolution--to study these materials. The appearance of a monoclonal immunoglobulin band is identical in both immunofixation and standard gel electrophoresis, a feature that allows unambiguous identification of a protein as to its heavy-chain class and light-chain type. Because antigen and antibody are placed in contact almost immediately after electrophoresis, interfering diffusion does not occur and even extremely small bands can be demonstrated and characterized.


The following articles in journals at HighWire Press have cited this article:


Home page
 Clin. Cancer Res.Home page
M. L. McMaster, G. Csako, T. R. Giambarresi, L. Vasquez, M. Berg, S. Saddlemire, B. Hulley, and M. A. Tucker
Long-term Evaluation of Three Multiple-Case Waldenstrom Macroglobulinemia Families
Clin. Cancer Res., September 1, 2007; 13(17): 5063 - 5069.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Chem.Home page
M. Attaelmannan and S. S. Levinson
Understanding and Identifying Monoclonal Gammopathies
Clin. Chem., August 1, 2000; 46(8): 1230 - 1238.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 1976 by the American Association for Clinical Chemistry.