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Clinical Chemistry 22: 341-345, 1976;
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Clinical Chemistry, Vol 22, 341-345, Copyright © 1976 by American Association for Clinical Chemistry

Gas-chromatographic analysis for succinimide anticonvulsants in serum: macro- and micro-scale methods

J Bonitati

A gas-chromatographic analysis for the succinimide anticonvulsant drugs- -ethosuximide, methsuximide, and phensuximide--in 1.0 ml of serum was modified to improve its reliability, speed, and precision. A separate procedure for 10-100 mul of serum was also developed. Neither method requires an initial preparation of derivatives. The working range of each method is about 10-100 mg/liter for the macro-method, 2-100 mg/liter for the micro-method. The methsuximide metabolite, N- desmethylmethsuximide, is included in both methods. Concentrations of N- desmethylmethsuximide in the blood of two patients with petit mal epilepsy are reported.




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Copyright © 1976 by the American Association for Clinical Chemistry.