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Clinical Chemistry 22: 379-380, 1976;
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Clinical Chemistry, Vol 22, 379-380, Copyright © 1976 by American Association for Clinical Chemistry

Modified colorimetric method for procainamide in plasma

DS Sitar, DN Graham, RE Rangno, LR Dusfresne and RI Ogilvie

We describe a modified colorimetric method for determining procainamide in plasma by use of a diazotization and coupling reaction with N-(1- naphthyl)-ethylenediamine dihydrochloride (Marshall's reagent). The sensitivity of the assay is increased twofold over the originally reported colorimetric method, and the lower limit of detection for the assay of a 1.0-ml plasma sample has been decreased to 0.5 mg/liter.




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Copyright © 1976 by the American Association for Clinical Chemistry.