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Clinical Chemistry 22: 528-531, 1976;
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Clinical Chemistry, Vol 22, 528-531, Copyright © 1976 by American Association for Clinical Chemistry

Effect of tobramycin on urinary gamma-glutamyltransferase activity: Studies in a case of renal carcinoma

PR Beck and AK Chaudhuri

Gamma-Glutamyltransferase activity was studied in a man presenting with recurrent septicemia owing to pyonephrosis and renal carcinoma. Increased activity in the urine was ascribable to administration of the aminoglycoside antibiotic, tobramycin. That the renal carcinoma did not contribute to the increased values was confirmed by homogenization and enzyme histochemistry of the tumor. Although the activity of this enzyme in serum was greater than normal, this persisted postoperatively, and thus was not related to the renal carcinoma.




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Copyright © 1976 by the American Association for Clinical Chemistry.