Clinical Chemistry
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Clinical Chemistry 22: 602-606, 1976;
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Clinical Chemistry, Vol 22, 602-606, Copyright © 1976 by American Association for Clinical Chemistry

Radioimmunoassay of bile acids in serum

LM Demers and G Hepner

We developed four radioimmunoassay procedures for the determination of glycine-conjugated bile acids in serum. Antibodies to two primary bile acids, cholylgycine and chenodeoxycholylglycine, and to two secondary bile acids, sulfolithocholylglycine and deoxycholylglycine, were raised in rabbits after the acids were covalently linked to albumin by use of the carbodiimide reaction. Assay sensitivity for each of these bile acids is in the picomole range with the standard curve extending from 10-80 pmol. The concentration of bile acids in serum increased in various states of liver disease and its measurement appears to be an extremely sensitive indicator of liver function.


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Home page
 Arch Pediatr Adolesc MedHome page
L. M. Demers and J. D. Lloyd-Still
Serum Bile Acid Levels in Protracted Diarrhea of Infancy
Arch Pediatr Adolesc Med, October 1, 1978; 132(10): 1001 - 1003.
[Abstract] [PDF]

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 Arch Pediatr Adolesc MedHome page
J. D. LLOYD-STILL, J. O. SHERMAN, J. BOGGS, and L. M. DEMERS
Erythromycin Estolate Hepatotoxicity
Arch Pediatr Adolesc Med, March 1, 1978; 132(3): 320 - 320.
[Abstract] [PDF]


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Copyright © 1976 by the American Association for Clinical Chemistry.