Clinical Chemistry
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Clinical Chemistry 22: 749-753, 1976;
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Clinical Chemistry, Vol 22, 749-753, Copyright © 1976 by American Association for Clinical Chemistry

Radioimmunoassay, enzyme immunoassay, spectrophotometry, and gas-liquid chromatography compared for determination of phenobarbital and diphenylhydantoin

V Spiehler, L Sun, DS Miyada, SG Sarandis, ER Walwick, MW Klein, DB Jordan and B Jessen

Sera from epileptic patients were assayed for phenobarbital and diphenylhydantoin by four different analytical procedures. Quantitative results obtained by radioimmunoassay (I) and enzyme immunoassay (II) were compared to each other and to the results obtained on aliquots of the same sample by gas-liquid chromatography (III) and ultraviolet spectrophotometry (IV). For phenobarbital the correlation coefficients were I vs. II, 0.909; I vs. III, 0.947; II vs. III, 0.917; I vs. IV, 0.950; II vs. IV, 0.953. For diphenylhydantoin the correlation coefficients were I vs. II, 0.953; I vs. III, 0.951; II vs. III, 0.957; I vs. IV, 0.862; II vs. IV, 0.898. The immunoassays can be substituted for liquid chromatography or ultraviolet spectrophotometry without changing the resulting clinical interpretations.


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 Arch NeurolHome page
W. R. Garnett, B. L. Carter, and J. M. Pellock
Effect of Calcium and Antacids on Phenytoin Bioavailability
Arch Neurol, July 1, 1980; 37(7): 467 - 467.
[Abstract] [PDF]


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Copyright © 1976 by the American Association for Clinical Chemistry.