Clinical Chemistry
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Clinical Chemistry 22: 843-846, 1976;
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Clinical Chemistry, Vol 22, 843-846, Copyright © 1976 by American Association for Clinical Chemistry

Results of a nine-laboratory survey of forensic toxicology proficiency

EC Dinovo and LA Gottschalk

Toxicological determinations are crucial to coroners' or medical examiners' judgments that drugs are significantly involved in a death. However, differences in laboratory procedures, thoroughness of screening, and limits of detection may result in artifactual differences in the toxicological results and the subsequent interpretations of them. To test this possibility, we conducted a toxicology proficiency-testing survey of nine collaborating laboratories. The results for the proficiency samples point out starting interlaboratory differences in accuracy and precision of detection of drugs. These observed variations in toxicological proficiency may introduce a significant source of error in drug-death statistics and in epidemiological deductions based on these statistics.


The following articles in journals at HighWire Press have cited this article:


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 Hum Exp ToxicolHome page
T. Rygnestad, K. Aarstad, K. Gustafsson, and U. Jenssen
The Clinical Value of Drug Analyses in Deliberate Self-Poisoning
Human and Experimental Toxicology, January 1, 1990; 9(4): 221 - 230.
[Abstract] [PDF]

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 Arch Intern MedHome page
A. S. Brett
Implications of Discordance Between Clinical Impression and Toxicology Analysis in Drug Overdose
Arch Intern Med, February 1, 1988; 148(2): 437 - 441.
[Abstract] [PDF]

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 Arch Intern MedHome page
A. S. Brett, N. Rothschild, R. Gray, and M. Perry
Predicting the Clinical Course in Intentional Drug Overdose: Implications for Use of the Intensive Care Unit
Arch Intern Med, January 1, 1987; 147(1): 133 - 137.
[Abstract] [PDF]


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Copyright © 1976 by the American Association for Clinical Chemistry.